Dopamine dysregulation by over secretion, is not a function of genetic damage or mutation, it is an overly enthusiastic response to life, praising life, obsessive pleasure in life, and over reward for love of life. Christianity has dealt with it by the habitual depression of the dyslexic, which is what Jesus was, Buddhism dealt with it by the ritual meditation of the monk, who was always afflicted with dop[amine dysregulation. Buddha is the religion of the dopamine dysregulation of life loving, Christianity is the depressive response to depressive subordination of social status by the dyslexic and illiterate. Buddha was a bon viveur royal, Jesus was a depressive tradesman, harried by constant depressive hard work.